Evaluation of multiple matrices to assess applicability of Minimum Reporting Levels for commonly abused stimulants

Code: 23A08VN

Three commonly used stimulants (amphetamine, methylphenidate and modafinil) will be evaluated in the study. Therapeutic doses of each drug will be administered once a day to ten healthy participants (five males and five females) for five days. Paired collections of urine, dried blood spots and serum will be collected from each participant, once a day. Collections will be performed during the administration phase and for seven days after cessation of use. Concentrations of the primary target compound will be measured by LC/MS to determine the matrix that best reflects circulating levels. A time course of elimination will be determined and the possibility of compound specific thresholds will also be evaluated.